产品货号：
Z28642
中文名称：
TMEM16A/DOG1/ANO1抗体
英文名称：
Anti-TMEM16A/DOG1/ANO1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TMEM16A/DOG1/ANO1 Antibody |
| 指标别名 | ANO1;Anoctamin 1;DOG1;ORAOV2;TAOS2;TMEM16A;TMEM16A/DOG1;Transmembrane protein 16A |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,FCM |
| 基因名称 | ANO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human ANO1 (QQIHKEK VLMVELFMREEQDKQQLLETWMEKERQKDE). |
| 实际分子量 | 130KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Anoctamin-1 (ANO1),also known as oral cancer overexpressed 2 (ORAOV2) or tumor-amplified and overexpressed sequence 2(TMEM16A),is a protein that in humans is encoded by the ANO1 gene.This gene belongs to a family of membrane proteins containing 8 transmembrane segments,and it is mapped to 11q13.3.ANO1 is a candidate calcium-activated chloride channel that mediates receptor-activated chloride currents in diverse physiologic processes,and it is thought to be responsible for a voltage-sensitive calcium-activated chloride current.Its overexpression was reported in esophageal squamous cell carcinoma and breast cancer progression Crofelemer,an antidiarrhoeal,inhibits this channel.ANO1 has eight transmembrane domains,its pore is large and non-selective,allowing other negatively charged species to permeate. |
| Uniprot ID | Q5XXA6 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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