产品货号：
Z28510
中文名称：
TLR3抗体
英文名称：
Anti-TLR3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TLR3 Antibody |
| 指标别名 | CD283;TLR3;toll like receptor 3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ELISA |
| 基因名称 | TLR3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human TLR3 recombinant protein (Position:F502-D648). |
| 实际分子量 | 120KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | TLR3(Toll-like receptor 3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene.The TLR3 gene is mapped to chromosome 4q35 by fluorescence in situ hybridization.TLR3 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system.TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents,and mediate the production of cytokines necessary for the development of effective immunity.The various TLRs exhibit different patterns of expression.This receptor is most abundantly expressed in placenta and pancreas,and is restricted to the dendritic subpopulation of the leukocytes.It recognizes dsRNA associated with viral infection,and induces the activation of NF-κB and the production of type I interferons.It may thus play a role in host defense against viruses.TLR3 recognizes double-stranded RNA,a form of genetic information carried by some viruses such as retroviruses.Upon recognition,TLR3 induces the activation of NF-κB to increase production of type I interferons which signal other cells to increase their antiviral defenses.Double-stranded RNA is also recognised by the cytoplasmic receptors RIG-I and MDA-5.TLR3 displays a protective role in mouse models of atherosclerosis.[4] In addition,TLR3 activators show effects on human vascular cells. |
| Uniprot ID | O15455 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 (ELISA)： 1:100～1000 |
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