产品货号：
Z28458
中文名称：
TBC1D10C抗体
英文名称：
Anti-TBC1D10C Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TBC1D10C Antibody |
| 指标别名 | EPI64C;CARABIN;Carabin;TBC1 domain family member 10C |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | TBC1D10C |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Carabin antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Carabin.The immunogen is located within the last 50 amino acids of Carabin. |
| 计算分子量 | 50kDa |
| 成分 | Carabin Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Carabin Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response,triggering a cascade of signaling pathways that ultimately lead to T-cell activation.Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin,a protein phosphatase involved in multiple signaling pathways including T-cell activation,resulted in the identification of Carabin,a member of the TBC1 domain family of proteins,as a calcineurin-binding protein.Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation,further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway,suggesting that Carabin may also mediate crosstalk between calcineurin and Ras.Carabin antibody does not recognize TBC1D10A or TBC1D10B.Carabin is known to exist in multiple isoforms. |
| Uniprot ID | Q8IV04 |
| 基因名全称 | TBC1 domain family,member 10C |
| 蛋白名全称 | TBC1 domain family,member 10C |
| 推荐稀释比 | Carabin antibody can be used for detection of Carabin by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.Antibody validated:Western Blot in human samples and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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