产品货号：
Z28344
中文名称：
TMP21/TMED10抗体
英文名称：
Anti-TMP21/TMED10 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TMP21/TMED10 Antibody |
| 指标别名 | P24(DELTA);p24delta;S31I125;S31III125;TMED10;Tmp 21 I;TMP21;Transmembrane protein Tmp21 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | TMED10 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TMP21 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TMP21.The immunogen is located within amino acids 160 - 210 of TMP21. |
| 计算分子量 | 25kDa |
| 成分 | TMP21 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TMP21 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport.More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein.The presenilin complex is composed of the proteins APH1,nicastrin,and PEN2 in addition to presenilin-1.Together,these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease.Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex.Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity,and increased Abeta production,demonstrating that TMP21 can modulate gamma-secretase activity. |
| Uniprot ID | P49755 |
| 基因名全称 | Transmembrane emp24-like trafficking protein 10 (yeast) |
| 蛋白名全称 | Transmembrane emp24-like trafficking protein 10 (yeast) |
| 推荐稀释比 | TMP21 antibody can be used for detection of TMP21 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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