产品货号：
Z28148
中文名称：
TBC1D4抗体
英文名称：
Anti-TBC1D4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TBC1D4 Antibody |
| 指标别名 | TBC1D4;AS160;KIAA0603;TBC1 domain family member 4;Akt substrate of 160kDa;AS160 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | TBC1D4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human TBC1D4 recombinant protein (Position:K1118-P1298). |
| 实际分子量 | 160KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | AS160?(Akt substrate of 160kDa),which was originally known as?TBC1 domain family member 4?(TBC1D4),?is a Rab?GTPase-activating?protein?that in humans is encoded by the?TBC1D4?gene.This gene is a member of the Tre-2/BUB2/CDC16 domain family.This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4),important for removing glucose from the bloodstream into skeletal muscle and fat tissues.Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane,suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions.When exposed to insulin,this protein is phosphorylated,dissociates from GLUT4 vesicles,resulting in increased GLUT4 at the cell surface,and enhanced glucose transport.Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface.Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. |
| Uniprot ID | O60343 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | TBC1 domain family member 4 |
| 蛋白名全称 | TBC1 domain family member 4 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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