产品货号：
Z28129
中文名称：
Thymidylate synthase/TYMS抗体
英文名称：
Anti-Thymidylate synthase/TYMS Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Thymidylate synthase/TYMS Antibody |
| 指标别名 | HsT422;Thymidylate synthase;thymidylate synthetase;TMS;TS;TSase;TYMS |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | TYMS |
| 抗体来源 | Sheep |
| 抗体类型 | IgG |
| 免疫原 | Anti-THYMIDYLATE SYNTHASE was purified from rabbit serum after repeated immunizations with recombinant human Thymidylate Synthase (36kDa) produced in E.coli. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-THYMIDYLATE SYNTHASE IgG fraction is directed against human Thymidylate Synthase and is useful in determining its presence in various assays.Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation,the enzyme is an important target for cancer chemotherapeutic drugs,specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.In general,this antibody can detect antigen in a variety of human cells and tissues,as well as bacteria,African green monkey,rat and mouse.Somewhat lower dilutions may be required in some non-human cell lines.?Anti-Thymidylate Synthase can detect Thymidylate Synthase by immunochemistry in proliferating cell cultures and tissues but does not stain nonproliferating cells.Normal colon mucosa shows weak staining;however,some colorectal cancer specimens show very strong staining. |
| 浓度 | 1mg/mL by UV absorbance at 280nm |
| 产品形态 | Lyophilized |
| 保存条件 | Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening. |
| 背景资料 | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor.This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair.The enzyme has been of interest as a target for cancer chemotherapeutic agents.It is considered to be the primary site of action for 5-fluorouracil,5-fluoro-2-prime-deoxyuridine,and some folate analogs.Expression of this gene and that of a naturally occurring antisense transcript rTSalpha vary inversely when cell-growth progresses from late-log to plateau phase.Diseases associated with Thymidylate synthase include Rectal Neoplasm and Dihydropyrimidine Dehydrogenase Deficiency.Anti-Thymidylate synthase is useful for researchers interested in Circadian Rhythm,Metabolism and cell cycle research. |
| Uniprot ID | P04818 |
| 推荐稀释比 | ELISA:1:10,000 - 1:50,000 IHC:User Optimized IF Microscopy:User Optimized WB:1:500 - 1:2,000 |
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