产品货号：
Z27902
中文名称：
TDP-43/TARDBP抗体
英文名称：
Anti-TDP-43/TARDBP Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TDP-43/TARDBP Antibody |
| 指标别名 | ALS10;TAR DNA binding protein;TAR DNA binding protein 43;TARDBP;TDP 43;TDP43 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | TARDBP |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TDP43 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human TDP43.The immunogen is located within amino acids 60 - 110 of TDP43. |
| 计算分子量 | 45kDa |
| 成分 | TDP43 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TDP43 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR.Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR),most likely through the association with the UG repeats at the 3'splice site.A hyperphosphorylated,ubiquitinated,and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive,tau-,and alpha-synuclein-negative frontotemporal dementia (FLTD-U).TDP43 is not related to TRBP1,and RNA binding protein that binds HIV-1 TAR RNA sequences. |
| Uniprot ID | Q13148 |
| 基因名全称 | TAR DNA binding protein |
| 蛋白名全称 | TAR DNA binding protein |
| 推荐稀释比 | TDP43 antibody can be used for detection of TDP43 by Western blot at 0.5 ～ 2μg/mL.Antibody can also be used for immunocytochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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