产品货号：
Z27800
中文名称：
SUMO1抗体
英文名称：
Anti-SUMO1 Antibody
产品规格：
500μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SUMO1 Antibody |
| 指标别名 | DAP 1;GAP modifying protein 1;GMP1;OFC10;PIC1;Sentrin;SMT3;SMT3 homolog 3;SMT3C;SMT3H3;SUMO 1;SUMO1;Ubiquitin like protein SMT3C;Ubiquitin like protein UBL1;UBL1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | SUMO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This purified antibody was prepared from rabbit serum after repeated immunizations with recombinant human SUMO protein. |
| 计算分子量 | 12kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation,salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer stated above.Assay by immunoelectrophoresis resulted in a single precipitin arc against anti-Rabbit Serum. |
| 浓度 | 5.0mg/mL by UV absorbance at 280nm |
| 产品形态 | Lyophilized |
| 保存条件 | Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening. |
| 背景资料 | Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO (small ubiquitin-like modifier) regulates various cellular processes,such as nuclear transport,signal transduction,stress responses and cell cycle progression.But,in contrast to ubiquination,sumoylation does not tag proteins for degradation by the 26S proteasome,but rather seems to enhance stability or modulate their subcellular compartmentalization.Ubiquitin-like proteins fall into two classes:the first class,ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin.Examples of UBLs are SUMO,Rub1 (also called Nedd8),Apg8 and Apg12.Proteins of the second class include parkin,RAD23 and DSK2,are designated ubiquitin-domain proteins (UDPs).These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other.In contrast to UBLs,UDPs are not conjugated to other proteins.Once covalently attached to cellular targets,SUMO regulates protein:protein and protein:DNA interactions,as well as localization and stability of the target protein.Sumoylation occurs in most eukaryotic systems,and SUMO is highly conserved from yeast to humans.Where invertebrates have only a single SUMO gene termed SMT3,three members of the SUMO family have been identified in vertebrates:SUMO-1 and the close homologues SUMO-2 and SUMO-3.SUMO has been called SMT3 (yeast),sentrin,PIC1,GMP1 and UBL1.SUMO has been shown to bind and regulate mammalian SP-RINGs (such as Mdm2,PIAS and PML),RanGAP1,RanBP2,p53,p73,HIPK2,TEL,c-Jun,Fas,Daxx,TNFRI,Topo-I,Topo-II,WRN,Sp100,IkB-a,Androgen receptor (AR),GLUT1/4,Drosophila Ttk69,Dorsal,CaMK,yeast Septins,and viral CMV-IE1/2,EBV-BZLF1,HPV/BPV-E1.These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes.SUMO has an apparent molecular weight of~12kDa and human SUMO-1 (a 101 amino acid polypeptide) shares 50% sequence identity with SUMO-2 and SUMO-3 and with yeast SMT3.SUMO and ubiquitin only show about 18% homology,but both possess a common three-dimensional structure characterized by a tightly packed globular fold with b-sheets wrapped around an a-helix. |
| Uniprot ID | P63165 |
| 基因名全称 | Ubiquitin-like protein SMT3 |
| 推荐稀释比 | ELISA:1:5,000 - 1:25,000 WB:1:500 - 1:3,000 |
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