产品货号：
Z27766
中文名称：
TFEB抗体
英文名称：
Anti-TFEB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TFEB Antibody |
| 指标别名 | AlphaTFEB;bHLHe35;TCFEB;TFEB;transcription factor EB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,FCM,ELISA |
| 基因名称 | TFEB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human TFEB recombinant protein (Position:A214-H326). |
| 实际分子量 | 60KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Transcription factor EB is a protein that in humans is encoded by the TFEB gene.TFEB is a master gene for lysosomal biogenesis.It encodes a transcription factor that coordinates expression of lysosomal hydrolases,membrane proteins and genes involved in autophagy.Upon nutrient depletion and under aberrant lysosomal storage conditions such as in lysosomal storage diseases,TFEB translocates from the cytoplasm to the nucleus,resulting in the activation of its target genes.TFEB overexpression in cultured cells induces lysosomal biogenesis,exocytosis and autophagy.Viral-mediated TFEB overexpression in cellular and mouse models of lysosomal storage disorders and in common neurodegenerative diseases such as Huntington,Parkinson and Alzheimer diseases,resulted in intracellular clearance of accumulating molecules and rescue of disease phenotypes.TFEB is activated by PGC1-alpha and promotes reduction of htt aggregation and neurotoxicity in a mouse model of Huntington disease.TFEB overexpression has been found in patients with renal cell carcinoma and pancreatic cancer and was shown to promote tumorogenesis via induction of varius oncogenic signals. |
| Uniprot ID | P19484 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P). |
| 基因名全称 | transcription factor EB |
| 蛋白名全称 | Transcription factor EB |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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