产品货号：
Z27552
中文名称：
SUV39H2抗体
英文名称：
Anti-SUV39H2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SUV39H2 Antibody |
| 指标别名 | H3 K9 HMTase 2;KMT1B;Lysine N methyltransferase 1B;Su(var)3 9 homolog 2;SUV39H2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | SUV39H2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human SUV39H2 recombinant protein (Position:A6-N410). |
| 实际分子量 | 47KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Histone-lysine N-methyltransferase SUV39H2 is an enzyme that in humans is encoded by the SUV39H2 gene.Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate.H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones.Mainly functions in heterochromatin regions,thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats.SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes,such as cell cycle regulation,transcriptional repression and regulation of telomere length.May participate in regulation of higher-order chromatin organization during spermatogenesis.Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1,contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
| Uniprot ID | Q9H5I1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | suppressor of variegation 3-9 homolog 2 |
| 蛋白名全称 | Histone-lysine N-methyltransferase SUV39H2 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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