产品货号：
Z27417
中文名称：
STAT5A抗体
英文名称：
Anti-STAT5A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-STAT5A Antibody |
| 指标别名 | MGF;STAT5;STAT5A |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | STAT5A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human STAT5a(735-751aa YNMYPQNPDHVLDQDGE). |
| 实际分子量 | 90～95KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | STAT5(Signal transducer and activator of transcription 5) also known as STAT5A,MGF,is a protein that serve the dual function of signal transducers and activators of transcription in cells exposed to signaling polypeptides.Hou et al.(1995)°Cloned the human STAT5°CDNA from an umbilical vein endothelial cell library and found that it encodes a 794-amino acid polypeptide with a predicted mass of approximately 90.5kD.To analyze the possible role of STAT5 in human GH-induced proliferation,Friedrichsen et al.(2001) expressed a dominant-negative STAT5 mutant,STAT5A-delta-749,in INS-1 cells under the control of a doxycycline-inducible promoter by stable transfection.°Chromatin immunoprecipitation analysis confirmed direct binding of STAT5 to the HIF2A promoter 344bp upstream of the HIF2A start site.STAT5 overexpression independently resulted in erythroid commitment in megakaryocytic-erythroid progenitors,which was abrogated by knockdown of GATA1.STAT5 is responsible for the immediate-early induction of the long isoform of the BCL2-related protein in erythroid cells through direct binding to the promoter of the BCLX gene. |
| Uniprot ID | P42229 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | signal transducer and activator of transcription 5A |
| 蛋白名全称 | Signal transducer and activator of transcription 5A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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