产品货号：
Z27334
中文名称：
STS 1/UBASH3B抗体
英文名称：
Anti-STS 1/UBASH3B Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-STS 1/UBASH3B Antibody |
| 指标别名 | Cbl interacting protein p70;KIAA1959;p70;STS 1;STS1;UBASH3B;UBASH3B/STS 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | UBASH3B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1. |
| 计算分子量 | 73kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity purified antibody is directed against mouse Sts-1 protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest reactivity with this protein from mouse,human,rat and dog based on 100% homology for the immunogen sequence.Cross-reactivity with Sts-1 homologues from other sources has not been determined. |
| 浓度 | 0.95mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.Sts-1 and Sts-2 (formerly p70 and Clip4,respectively) have been found to interact with Cbl,an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.Sts-1 and Sts-2 contain SH3 domains that interact with Cbl,Ub-associated domains,which bind directly to mono-Ub or to the EGFR/Ub chimera,as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors,which in turn affect the extent and duration of the T cell response to foreign pathogens. |
| Uniprot ID | Q8TF42 |
| 基因名全称 | Ubiquitin-associated and SH3 domain-containing protein B |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 IHC:4μg/mL IF Microscopy:User Optimized WB:1:500 - 1:3,000 |
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