产品货号：
Z27221
中文名称：
SMN1/2抗体
英文名称：
Anti-SMN1/2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SMN1/2 Antibody |
| 指标别名 | C BCD541;Component of gems 1;Gemin 1;SMN;SMN1;SMN1;SMN;SMN2;SMNC;SMNT;Survival motor neuron protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | SMN1/SMN2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human SMN1/2(22-52aa RRGTGQSDDSDIWDDTALIKAYDKAVASFKH),identical to the related mouse and rat sequences. |
| 实际分子量 | 39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | This gene is part of a 500kb inverted duplication on chromosome 5q13.This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions.The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region.The telomeric and centromeric copies of this gene are nearly identical and encode the same protein.However,mutations in this gene,the telomeric copy,are associated with spinal muscular atrophy;mutations in the centromeric copy do not lead to disease.The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy.The critical sequence difference between the two genes is a single nucleotide in exon 7,which is thought to be an exon splice enhancer.Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1,2a,2b,and 3-8.It is thought that gene conversion events may involve the two genes,leading to varying copy numbers of each gene.The protein encoded by this gene localizes to both the cytoplasm and the nucleus.Within the nucleus,the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs).This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4,and also interacts with several proteins known to be involved in the biogenesis of snRNPs,such as hnRNP U protein and the small nucleolar RNA binding protein.Multiple transcript variants encoding distinct isoforms have been described. |
| Uniprot ID | Q16637/Q16637 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | survival of motor neuron 1,telomeric/survival of motor neuron 2,centromeric |
| 蛋白名全称 | Survival motor neuron protein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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