产品货号：
Z27055
中文名称：
SMAD6抗体
英文名称：
Anti-SMAD6 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SMAD6 Antibody |
| 指标别名 | SMAD family member 6;AOVD2;HsT17432;MADH6;MADH7;SMAD6 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | SMAD6 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SMAD6(436-452aa IKVFDFERSGLQHAPEP). |
| 实际分子量 | 53KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Mothers against decapentaplegic homolog 6,also known as SMAD6,is a protein that in humans is encoded by the SMAD6 gene.It belongs to the SMAD family of proteins,which belongs to the TGFbeta superfamily of modulators.By PCR screening of a somatic cell hybrid panel and YACs,this gene was mapped to 15q22.31.This gene acts as a mediator of TGF-beta and BMP antiflammatory activity.It can suppress 1L 1R-TLR signaling through its direct interaction with PEL1 and prevent NF-kappa-B activation,nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.SMAD6 may play a role in blocking the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding and binding to regulatory elements in target promoter regions. |
| Uniprot ID | O43541 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | SMAD family member 6 |
| 蛋白名全称 | Mothers against decapentaplegic homolog 6 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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