产品货号：
Z26997
中文名称：
SOCS3抗体
英文名称：
Anti-SOCS3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SOCS3 Antibody |
| 指标别名 | ATOD4;CIS 3;CIS3;Cish3;SOCS 3;SOCS3;SOCS-3;SSI 3;SSI3;STAT induced STAT inhibitor 3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC |
| 基因名称 | SOCS3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human SOCS3(71-85aa RDSSDQRHFFTLSVK),identical to the related mouse sequence,different from the related rat sequence by one amino acid. |
| 实际分子量 | 28～30KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SOCS3(Suppressor of cytokine signaling 3) is a protein that in humans is encoded by the SOCS3 gene.SOCS3 is transiently expressed by multiple cell lineages within the immune system and functions predominantly as a negative regulator of cytokines that activate the JAK-STAT3 pathway.This gene encodes a member of the STAT-induced STAT inhibitor(SSI),also known as suppressor of cytokine signaling(SOCS),family.SSI family members are cytokine-inducible negative regulators of cytokine signaling.The expression of this gene is induced by various cytokines,including IL6,IL10,and interferon(IFN)-gamma.The protein encoded by this gene can bind to JAK2 kinase,and inhibit the activity of JAK2 kinase.For signaling of IL-6,Epo,GCSF and Leptin,binding of SOCS3 to the respective cytokine receptor has been found to be crucial for the inhibitory function of SOCS3.Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis,and placental development. |
| Uniprot ID | O14543 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | suppressor of cytokine signaling 3 |
| 蛋白名全称 | Suppressor of cytokine signaling 3(SOCS-3) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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