产品货号：
Z26969
中文名称：
SPG11抗体
英文名称：
Anti-SPG11 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SPG11 Antibody |
| 指标别名 | KIAA1840,Spastic paraplegia 11 protein,SPATACSIN,SPG11 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | SPG11 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SPG11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPG11.The immunogen is located within amino acids 2360 - 2410 of SPG11. |
| 计算分子量 | 279kDa |
| 成分 | SPG11 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SPG11 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.?Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration.Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC.Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage.It is expressed in all structures of the brain,with a high expression in the cerebellum.SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC.Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.?Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism. |
| Uniprot ID | Q96JI7 |
| 基因名全称 | Spastic paraplegia 11 (autosomal recessive) |
| 蛋白名全称 | Spastic paraplegia 11 (autosomal recessive) |
| 推荐稀释比 | SPG11 antibody can be used for detection of SPG11 by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.Antibody validated:Western Blot in mouse samples and Immunohistochemistry in mouse samples.All other applications and species not yet tested. |
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