产品货号：
Z26870
中文名称：
RSL1D1抗体
英文名称：
Anti-RSL1D1 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RSL1D1 Antibody |
| 指标别名 | PBK1;PBK-1;PBK 1;CATX-11;CATX11;RSL1D1;Cellular senescence inhibited gene protein;CSIG;L12;Ribosomal L1 domain containing protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IF,WB |
| 基因名称 | RSL1D1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human PBK1. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody is specific for human PBK1 protein.A BLAST analysis was used to suggest limited cross-reactivity with PBK1 from mouse based on a 75% homology with the immunizing sequence.Cross-reactivity with PBK1 from other sources has not been determined. |
| 浓度 | 1.1mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | PBK1 protein (also known as Ribosomal L1 domain-containing protein 1,cellular senescence-inhibited gene protein,and CATX-11) was isolated from highly invasive first trimester trophoblast cells and has been proposed to regulate their naturally occurring invasive behavior (Huch et al.,1998).PBK1 was also found to be over-expressed in non-small-cell lung cancer (NSCLC) cells (Petroziello et al.,2004).A recent study suggests that PBK1 may up-regulate the urokinase-type plasminogen activator (uPA) gene,which plays an important role in cellular matrix degradation and activation of other protease systems involved in cell invasion (Tong et al.,2005).The cellular localization dynamics of PBK1,as well as the data from its yeast homologue (Cic1p/Nsa3p) suggest that PBK1 is essential for ribosome biogenesis (Fatica et al.,2003).Thus,PBK1 could be controlling cell proliferation by regulating the level of ribosome production.It is hypothesized that PBK1 is involved in regulating both,cell proliferation and invasiveness,therefore playing a dual function in cancer cells transformation. |
| Uniprot ID | O76021 |
| 推荐稀释比 | ELISA:1:2,500 - 1:10,000 IF Microscopy:1:100 IP:1:100 WB:1:500 - 1:2,000 |
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