产品货号：
Z26762
中文名称：
SMARCB1抗体
英文名称：
Anti-SMARCB1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SMARCB1 Antibody |
| 指标别名 | BAF47;BRG1 associated factor 47;hSNF5;hSNFS;INI1;INI-1;Integrase interactor 1 protein;RDT;Sfh1p;SMARCB1;SNF5;SNF5 homolog;SNF5L1;Snr1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,rat |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | SMARCB1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human SNF5/SMARCB1 recombinant protein (Position:E105-D358). |
| 实际分子量 | 44KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SMARCB1(SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1),also known as SNF5,INI1 or MALIGNANT RHABDOID TUMOR SUPPRESSOR,is a protein that in humans is encoded by the SMARCB1 gene.The SMARCB1 gene encodes a subunit of the SWI/SNF ATP-dependent chromatin-remodeling complex.The SMARCB1 gene maps to chromosome 22q11.2(Versteege et al.,1998).Wu et al.(2002) noted that GADD34(PPP1R15A) and SNF5 can coexist in a trimeric complex with chimeric leukemic HRX(MLL) fusion proteins,leading to inhibition of GADD34-mediated apoptosis.By mutation analysis,they showed that the GADD34 region homologous to the HSV-1 ICP34.5 protein was necessary for interaction with SNF5.SNF5 could bind independently with the protein phosphatase-1(PP1) catalytic subunit(PPP1CA) and stimulate its activity in solution and in complex with GADD34.SNF5 and PP1 did not compete for GADD34 binding,but rather formed a stable trimeric complex with GADD34.Wu et al.(2002) proposed that GADD34 mediates growth suppression,at least in part,through its interaction with SNF5.They suggested that SNF5 may function as a regulatory subunit of PP1,either independently or together with GADD34. |
| Uniprot ID | Q12824 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | SWI/SNF related,matrix associated,actin dependent regulator of chromatin,subfamily b,member 1 |
| 蛋白名全称 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 |
相关搜索：SMARCB1抗体，SMARCB1多抗，Anti-SMARCB1 Antibody