产品货号：
Z26653
中文名称：
SKA2抗体
英文名称：
Anti-SKA2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SKA2 Antibody |
| 指标别名 | spindle and kinetochore associated complex subunit 2;FAM33A;SKA2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB |
| 基因名称 | SKA2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SKA2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human SKA2.The immunogen is located within the first 50 amino acids of SKA2. |
| 计算分子量 | 14kDa |
| 成分 | SKA2 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SKA2 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Upon entry into mitosis,the cell's microtubule (MT) network forms the mitotic spindle,allowing the segregation of paired chromosomes.Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for the proper attachment of the chromosomes to the spindle MTs.A recently discovered spindle and kinetochore complex,comprised of proteins SKA1,SKA2,and SKA3,has been found to be required for stable KT-MT interactions and timely anaphase onset.Depletion of either SKA1 or SKA2 by siRNA results in the loss of both proteins from the KT,but does not impact overall KT structure.Cells depleted of the SKA complex undergo a prolonged checkpoint-dependent delay in a metaphase-like state,indicating the importance of the SKA complex in the maintenance of the metaphase plate and spindle checkpoint silencing.SKA2 has also been shown to interact with glucocorticoid receptors and to be involved in glucocorticoid signaling and cell proliferation. |
| Uniprot ID | Q8WVK7 |
| 基因名全称 | Spindle and kinetochore associated complex subunit 2 |
| 蛋白名全称 | Spindle and kinetochore associated complex subunit 2 |
| 推荐稀释比 | SKA2 antibody can be used for detection of SKA2 by Western blot at 0.5 ～ 1μg/mL.Antibody validated:Western Blot in mouse samples.All other applications and species not yet tested. |
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