产品货号：
Z26519
中文名称：
SHP2/PTPN11抗体
英文名称：
Anti-SHP2/PTPN11 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SHP2/PTPN11 Antibody |
| 指标别名 | BPTP3;CFC;NS1;PTP 1D;PTP 2C;PTP2C;PTPN11;SH PTP2;SH PTP3;SHP 2;SHP2;SHPTP2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | PTPN11 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SHP2(578-592aa EDSARVYENVGLMQQ),identical to the related rat and mouse sequences. |
| 实际分子量 | 68KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The tyrosine phosphatase Shp2 is recruited into tyrosine-kinase signalling pathways through binding of its two amino-terminal SH2 domains to specific phosphotyrosine motifs,concurrent with its re-localization and stimulation of phosphatase activity.Shp2 can potentiate signalling through the MAP-kinase pathway and is required during early mouse development for gastrulation.Shp2 is specifically required in mesenchyme cells of the progress zone(PZ),directly beneath the distal ectoderm of the limb bud.Rather than integrating proliferative signals,Shp2 probably exerts its effects on limb development by influencing cell shape,movement or adhesion.Furthermore,the branchial arches,which also use Fgfs during bud outgrowth,similarly require Shp2.Thus,Shp2 regulates phosphotyrosine-signalling events during the complex ectodermal-mesenchymal interactions that regulate mammalian budding morphogenesis. |
| Uniprot ID | Q06124 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | protein tyrosine phosphatase,non-receptor type 11 |
| 蛋白名全称 | Tyrosine-protein phosphatase non-receptor type 11 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
相关搜索：SHP2/PTPN11抗体，SHP2抗体，PTPN11多抗，Anti-SHP2/PTPN11 Antibody