产品货号：
Z26467
中文名称：
Sestrin 2/SESN2抗体
英文名称：
Anti-Sestrin 2/SESN2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Sestrin 2/SESN2 Antibody |
| 指标别名 | HI95,SES2,SESN2,SEST2,Sestrin2,Sestrin-2 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | SESN2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2.The immunogen is located within amino acids 220 - 270 of SESTRIN2. |
| 计算分子量 | 54kDa |
| 成分 | SESTRIN2 antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SESTRIN2 antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | SESTRIN2,also known as Hi95,is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1).SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1,the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2).SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3),thereby protecting cells against energetic stress-induced death (4). |
| Uniprot ID | P58004 |
| 基因名全称 | Sestrin 2 |
| 蛋白名全称 | Sestrin 2 |
| 推荐稀释比 | SESTRIN2 antibody can be used for detection of SESTRIN2 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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