产品货号：
Z26390
中文名称：
SIX3抗体
英文名称：
Anti-SIX3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SIX3 Antibody |
| 指标别名 | SIX homeobox 3;HPE2;SIX3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | SIX3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Six3 (1-32aa MVFRSPLDLYSSHFLLPNFADSHHRSILLASS),different from the related mouse sequence by two amino acids. |
| 实际分子量 | 35KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Homeobox protein SIX3 is a protein that in humans is encoded by the SIX3 gene.This gene encodes a member of the sine oculishomeobox transcription factor family.The encoded protein plays a role in eye development.Mutations in SIX3 are the cause of a severe brain malformation,called holoprosencephaly type 2 (HPE2).In HPE2,the brain fails to separate into two hemispheres during early embryonic development,leading to eye and brain malformations,which result in serious facial abnormalities.A mutant zebrafish knockout model has been developed,in which the anterior part of the head was missing due to the atypical increase of Wnt1 activity.When injected with SIX3,these zebrafish embryos were able to successfully develop a normal forebrain.When SIX3 was turned off in mice,resulting in a lack of retina formation due to excessive expression of Wnt8b in the region where the forebrain normally develops.Both of these studies demonstrate the importance of SIX3 activity in brain and eye development. |
| Uniprot ID | O95343 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：SIX3抗体，SIX3多抗，Anti-SIX3 Antibody