产品货号：
Z26194
中文名称：
SAPAP1/DLGAP1抗体
英文名称：
Anti-SAPAP1/DLGAP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SAPAP1/DLGAP1 Antibody |
| 指标别名 | DLG associated protein 1;DAP-1;DAP-1-ALPHA;DAP-1-BETA;DAP1A;DLGAP1B;GKAP;SAPAP1;DLGAP1;hGKAP;SAPAP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | DLGAP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human DLGAP1 recombinant protein (Position:D17-Q319). |
| 实际分子量 | 130KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Disks large-associated protein 1 (DAP-1),also known as guanylate kinase-associated protein (GKAP),is a protein that in humans is encoded by the DLGAP1 gene.The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses.Glutamate is released from the presynaptic membrane into the synaptic cleft.Across the synaptic cleft glutamate binds to both ion channels and metabotropic glutamate receptors at the postsynapse,which expedite downstream signalling in the neuron.The postsynaptic density,a highly specialized matrix,which is attached to the postsynaptic membrane,controls this downstream signalling.The postsynaptic density also resets the synapse after each synaptic firing.It is composed of numerous proteins including a family of Discs large associated protein 1,2,3 and 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density.They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors,to signalling proteins and to components of the cytoskeleton.With the central localisation in the postsynapse,the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic and metabotropic glutamate receptors in response to synaptic activity.DLGAP family has been directly linked to a variety of psychological and neurological disorders. |
| Uniprot ID | O14490 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | DLG associated protein 1 |
| 蛋白名全称 | Disks large-associated protein 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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