产品货号：
Z25881
中文名称：
RELB抗体
英文名称：
Anti-RELB Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RELB Antibody |
| 指标别名 | I REL;IREL;RELB;Transcription factor RelB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,FCM |
| 基因名称 | RELB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human Rel B (219-252aa RHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNA),identical to the related mouse sequence. |
| 实际分子量 | 62KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RELB (v-rel reticuloendotheliosis viral oncogene homolog B) is also known as IREL.The International Radiation Hybrid Mapping Consortium assigned the RELB gene to chromosome 19.By RT-PCR and immunocytochemical analyses,Clark et al.(1999) showed that RELB expression correlated with dendritic cell activation.NF-kappa-B-inducing kinase is required for osteoclastogenesis in response to pathologic stimuli.Vaira et al.(2008) found that overexpression of Relb,but not Rela,rescued differentiation of mouse Nik -/- osteoclast precursors,indicating that blockade of the alternative NF-kappa-B pathway,rather than the classical NF-kappa-B pathway,is responsible for the osteoclastogenic defect in the absence of Nik.Using Relb -/- mice,they showed that Relb itself was required for Rankl-induced osteoclastogenesis in vitro and for TNF-induced bone resorption in vivo.Both Relb -/- and Nik -/- mice were resistant to tumor-mediated osteolysis.Vaira et al.(2008) concluded that the alternative NF-kappa-B pathway,via RELB,plays an essential and unique role in RANKL signaling toward osteoclast development. |
| Uniprot ID | Q01201 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | v-rel reticuloendotheliosis viral oncogene homolog B |
| 蛋白名全称 | Transcription factor RelB |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：RELB抗体，RELB多抗，Anti-RELB Antibody