产品货号：
Z25819
中文名称：
SCRAPPER/FBXL20抗体
英文名称：
Anti-SCRAPPER/FBXL20 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SCRAPPER/FBXL20 Antibody |
| 指标别名 | Fbl2,Fbl20,FBL2,F-box and leucine-rich repeat protein 20 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | FBXL20 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | SCRAPPER antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of the human SCRAPPER.The immunogen is located within the last 50 amino acids of SCRAPPER. |
| 计算分子量 | 48kDa |
| 成分 | SCRAPPER Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | SCRAPPER Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Members of the F-box protein family,such as Scrapper,are characterized by an approximately 40-amino acid F-box motif.SCF complexes,formed by SKP1,cullin,and F-box proteins,act as protein-ubiquitin ligases.Scrapper is selectively expressed in the brain,broadly expressed within the mouse CNS and is abundant at presynaptic membrane.Scrapper has orthologs in C.elegans,D.melanogaster,and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species.Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission.This identifies protein degradation as a mechanism for holding synaptic communication in check. |
| Uniprot ID | Q96IG2 |
| 基因名全称 | F-box and leucine-rich repeat protein 20 |
| 蛋白名全称 | F-box and leucine-rich repeat protein 20 |
| 推荐稀释比 | SCRAPPER antibody can be used for detection of SCRAPPER by Western blot at 0.5 ～ 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.Antibody validated:Western Blot in mouse samples and Immunohistochemistry in human samples.All other applications and species not yet tested. |
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