产品货号：
Z25201
中文名称：
RBL1抗体
英文名称：
Anti-RBL1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RBL1 Antibody |
| 指标别名 | CP107;p107;PRB1;RBL1;retinoblastoma like 1 (p107);Retinoblastoma like protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | RBL1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human p107(1048-1068aa QENDDVLLKRLQDVVSERANH),identical to the related rat and mouse sequences. |
| 实际分子量 | 121KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RBL1(Retinoblastoma-like 1),also known as Cullular Proteins p107,CP107 and 107,is a protein that in humans is encoded by the RBL1 gene.Ewen et al.(1991)used a partial cDNA for human p107 to map the gene to 20q11.by fluorescence in situ hybridization.Huppi et al.(1996)found that the mouse Rbl1 gene maps to the distal end of chromosome 2,as does also the E2f1 gene.The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1(RB1) gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation,as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen,with the SV40 large T-antigen binding only to the unphosphorylated form of each protein.In addition,both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters.Due to the sequence and biochemical similarities with the RB1 protein,it is though that the protein encoded by this gene may also be a tumor suppressor.Two transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P28749 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | retinoblastoma-like 1(p107) |
| 蛋白名全称 | Retinoblastoma-like protein 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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