产品货号：
Z25128
中文名称：
RNF216抗体
英文名称：
Anti-RNF216 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RNF216 Antibody |
| 指标别名 | RNF216;TRIAD3;UBCE7IP1;ZIN;E3 ubiquitin-protein ligase RNF216;RING finger protein 216;RING-type E3 ubiquitin transferase RNF216;Triad domain-containing protein 3;Ubiquitin-conjugating enzyme 7-interacting protein 1;Zinc finger protein inhibiting NF-kappa-B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | RNF216 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | TRIAD3A antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of mouse TRIAD3A.The immunogen is located within amino acids 120 - 170 of TRIAD3A. |
| 计算分子量 | 99kDa |
| 成分 | TRIAD3A Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | TRIAD3A Antibody is Ion exchange chromatography purified. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Activation of NF-百B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses.Signals from these receptors are relayed by a number of adapter molecules such as TRIF,TIRAP,and MyD88.Several regulatory mechanisms exist to control TLR signal transduction,including the inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR.Another mechanism is by the ubi-quitinization of selected TLRs by TRIAD3A,an E3 ubiquitin-protein ligase.TRIAD3A is a RING finger protein that can bind to TLR4 and TLR9,and to a lesser extent TLR3 and TLR5,catalyzing the ubiquitization of these molecules.Overexpression of TRIAD3A promoted the nearly complete degradation of TLR4 and TLR9;this reduction was reflected in the decreased signal-specific activation by ligands specific for these TLRs.Conversely,depletion of TRIAD3A resulted in enhanced TLR activation. |
| Uniprot ID | Q9NWF9 |
| 基因名全称 | Ring finger protein 216 |
| 蛋白名全称 | Ring finger protein 216 |
| 推荐稀释比 | TRIAD3A antibody can be used for detection of TRIAD3A by Western blot at 1 to 2μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in mouse samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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