产品货号：
Z25062
中文名称：
RBX1抗体
英文名称：
Anti-RBX1 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RBX1 Antibody |
| 指标别名 | Protein ZYP;RBX1;Regulator of cullins 1;ring box 1;RING box protein 1;RING finger protein 75;RNF75;ROC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | RBX1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 94-108 of Human ROC1 (C-terminal) coupled to KLH. |
| 成分 | 0.01% (w/v) Sodium Azide |
| 纯化方式 | This product is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration.This product reacts with human,mouse,C.elgans and zebra fish ROC1.Cross-reactivity may also occur with ROC1 from other sources.Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC2 and APC11. |
| 浓度 | 85mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | ROC1 also known as RING-box protein 1,Rbx1,Regulator of cullins 1,RING finger protein 75,and ZYP protein,is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes,which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression,signal transduction and transcription.ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34,and brings it into close proximity to the substrate.The RING-type zinc finger domain is essential for ubiquitin ligase activity.ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2.ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues. |
| Uniprot ID | P62877 |
| 推荐稀释比 | ELISA:1:2,000 - 1:10,000 IHC:User Optimized WB:1:500 - 1:1,000 |
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