产品货号：
Z24701
中文名称：
RAB5A抗体
英文名称：
Anti-RAB5A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-RAB5A Antibody |
| 指标别名 | Cell and organelle markers;Endosome Marker;RAB5;RAB5A;Ras related protein Rab 5A |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | RAB5A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Rab5 (179-215aa KKLPKNEPQNPGANSARGRGVDLTEPTQPTRNQCCSN),different from the related mouse and rat sequences by three amino acids. |
| 实际分子量 | 24KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | RAB5A (Ras-associated protein RAB5A),also called RAB5,is a protein that in humans is encoded by the RAB5A gene.RAB5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway.The RAB5A gene is mapped on 3p24.3.RAB5 is indispensable for a form of receptor tyrosine kinase-induced actin remodeling called circular ruffling.It signals to the actin cytoskeleton through RNTRE,a RAB5-specific GTPase-activating protein (GAP).RAB5 activity on phagosome membranes began to increase on disassembly of the actin coat encapsulating phagosomes.In addition,RAB5 activation is either continuous or repetitive for up to 10minutes,but it ends before the collapse of engulfed apoptotic cells.Expression of a dominant-negative mutant of RAB5 delayed this collapse of apoptotic thymocytes,showing a role for RAB5 in phagosome maturation. |
| Uniprot ID | P20339 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | RAB5A,member RAS oncogene family |
| 蛋白名全称 | Ras-related protein Rab-5A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry(Paraffin-embedded Section) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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