产品货号：
Z24581
中文名称：
PUMA/BBC3抗体
英文名称：
Anti-PUMA/BBC3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PUMA/BBC3 Antibody |
| 指标别名 | BBC3;JFY 1;JFY1;PUMA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | BBC3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human PUMA(145-159aa ADDLNAQYERRRQEE),identical to the related rat and mouse sequences. |
| 实际分子量 | 21KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The p53 upregulated modulator of apoptosis,or PUMA,is a pro-apoptotic member of the Bcl-2 protein family.The PUMA gene is located at 19q.PUMA transcript is contained within 4 exons,with the presumptive initiation codon in exon 2.The predicted 193-amino acid PUMA protein shares 91% amino acid identity with the murine sequence.Bcl-2 family members can form hetero- or homodimers,and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities.The expression of PUMA is regulated by the tumor suppressor p53,and PUMA has been shown to be involved in p53-mediated apoptosis.Additionally,PUMA encodes 2 BH3 domain-containing proteins,PUMA-alpha and PUMA-beta,that are produced through the use of an alternative first exon and are induced in cells following p53 activation.Furthermore,PUMA couples the nuclear and cytoplasmic proapoptotic functions of p53. |
| Uniprot ID | Q9BXH1 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | BCL2 binding component 3 |
| 蛋白名全称 | Bcl-2-binding component 3 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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