产品货号：
Z24383
中文名称：
Presenilin 1/PSEN1抗体
英文名称：
Anti-Presenilin 1/PSEN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Presenilin 1/PSEN1 Antibody |
| 指标别名 | AD3;FAD;Presenilin-1;Presenilin-1-Specific;Protein S182;PS 1;PS1;PS1 CTF12;PSEN1;PSNL1;S182 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM,ELISA |
| 基因名称 | PSEN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Presenilin 1/PS-1/PSEN1 recombinant protein (Position:M1-K76). |
| 实际分子量 | 53KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1;PSEN2) or in the amyloid precursor protein (APP).These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains).Presenilins are postulated to regulate APP processing through their effects on gamma-secretase,an enzyme that cleaves APP.Also,it is thought that the presenilins are involved in the cleavage of the Notch receptor,such that they either directly regulate gamma-secretase activity or themselves are protease enzymes.Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene,the full-length nature of only some have been determined. |
| Uniprot ID | P49768 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | presenilin 1 |
| 蛋白名全称 | Presenilin-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 |
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