产品货号：
Z24079
中文名称：
PKR/EIF2AK2抗体
英文名称：
Anti-PKR/EIF2AK2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PKR/EIF2AK2 Antibody |
| 指标别名 | eIF 2A protein kinase 2;EIF2AK1;EIF2AK2;P1/eIF 2A protein kinase;p68 kinase;PKR;PRKR;Protein kinase RNA activated |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,ICC/IF |
| 基因名称 | EIF2AK2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human PKR(511-551aa EKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHTC),different from the related mouse sequence by fifteen amino acids,and from the related rat sequence by thirteen amino acids. |
| 实际分子量 | 69KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | EIF2AK2 (Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2),also called PKR,is an enzyme that in humans is encoded by the EIF2AK2 gene.Activation of EIF2AK2 allows the kinase to phosphorylate its natural substrate,the alpha subunit of eukaryotic protein synthesis initiation factor-2,leading to the inhibition of protein synthesis.By FISH analysis,Squire et al.(1993) assigned the EIF2AK2 gene to the boundary between chromosome 2p22-p21.Ben-Asouli et al.(2002) showed that human gamma-interferon mRNA uses local activation of PKR in the cell to control its own translation yield.IFNG mRNA was found to activate PKR through a pseudoknot in its 5-prime untranslated region.Taylor et al.(1999) studied the mechanism underlying the resistance of hepatitis C virus (HCV) to interferon.They demonstrated that the HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PKR and the translation initiation factor EIF2-alpha,a target of PKR.E2 inhibited the kinase activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. |
| Uniprot ID | P19525 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | eukaryotic translation initiation factor 2-alpha kinase 2 |
| 蛋白名全称 | Interferon-induced,double-stranded RNA-activated protein kinase |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
相关搜索：PKR/EIF2AK2抗体，PKR抗体，EIF2AK2多抗，Anti-PKR/EIF2AK2 Antibody