产品货号：
Z24065
中文名称：
PKR/EIF2AK2抗体
英文名称：
Anti-PKR/EIF2AK2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PKR/EIF2AK2 Antibody |
| 指标别名 | eIF 2A protein kinase 2;EIF2AK1;EIF2AK2;P1/eIF 2A protein kinase;p68 kinase;PKR;PRKR;Protein kinase RNA activated |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | EIF2AK2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-PKR antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human PKR.The immunogen is located within the last 50 amino acids of PKR. |
| 计算分子量 | 62kDa |
| 成分 | PKR Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | PKR Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The interferon-inducible,double-stranded RNA (dsRNA)-dependent protein kinase PKR is a member of the eukaryotic initiation factor-2 alpha (eIF2-alpha) kinase family,possessing serine-threonine kinase activity and two dsRNA-binding motifs that acts as part of the innate immune system.Upon binding dsRNA,PKR undergoes a conformational change leading to its activation and its phosphorylation of the translation factor eIF2,resulting in a general shutdown of protein synthesis and induction of apoptosis through upregulation of caspase-8 and capsase-9 activity in order to prevent the production of more viruses.To evade the antiviral effects of PKR,viruses have evolved multiple mechanisms,such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus.More recently,PKR has been implicated in several neurodegenerative diseases including Alzheimer,Huntington,and amyotrophic lateral sclerosis. |
| Uniprot ID | P19525 |
| 基因名全称 | Eukaryotic translation initiation factor 2-alpha kinase 2 |
| 蛋白名全称 | Eukaryotic translation initiation factor 2-alpha kinase 2 |
| 推荐稀释比 | WB:1μg/mL;IF:20μg/mL;IHC:2.5～5μg/mL.Antibody validated:Western Blot in human and mouse samples;Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
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