产品货号：
Z23999
中文名称：
PPAR Gamma/PPARG抗体
英文名称：
Anti-PPAR Gamma/PPARG Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PPAR Gamma/PPARG Antibody |
| 指标别名 | CIMT1;NR1C3;PPAR gamma;PPARG;PPARG1;PPARG2;PPARgamma;PPARγ |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC |
| 基因名称 | PPARG |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human PPAR gamma(45-62aa PHYEDIPFTRTDPVVADY),different from the rat and mouse sequences by two amino acids. |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The peroxisome proliferator-activated receptors(PPARs) are a group of three nuclear receptor isoforms,PPAR gamma,PPAR alpha,and PPAR delta,encoded by different genes.PPARs are ligand-regulated transcription factors that control gene expression by binding to specific response elements(PPREs) within promoters.PPAR gamma is a transcription factor that has a pivotal role in adipocyte differentiation and expression of adipocyte-specific genes.The PPAR gamma1 and gamma2 isoforms result from alternative splicing and have ligand-dependent and -independent activation domains.PPAR gamma is a member of a family of nuclear receptors/ligand-dependent transcription factors,which bind to hormone response elements on target gene promoters.Ameshima et al.(2003) found that PPAR gamma is abundantly expressed in normal lung tissues,especially in endothelial cells,but that its expression is reduced or absent in the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe pulmonary hypertension.And they conclude that fluid shear stress decreases the expression of PPARgamma in endothelial cells and that loss of PPARgamma expression characterizes an abnormal,proliferating,apoptosis-resistant endothelial cell phenotype. |
| Uniprot ID | P37231 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | peroxisome proliferator-activated receptor gamma |
| 蛋白名全称 | Peroxisome proliferator-activated receptor gamma(PPAR-gamma) |
| 推荐稀释比 | Immunohistochemistry in paraffin section IHC-(P) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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