产品货号：
Z23984
中文名称：
PPARA抗体
英文名称：
Anti-PPARA Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PPARA Antibody |
| 指标别名 | hPPAR;NR1C1;PPAR;PPAR alpha;PPARA;PPARα |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,IF,IHC,WB |
| 基因名称 | PPARA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | PPAR alpha Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a N-Terminal region near amino acids 1-25 of mouse PPAR alpha. |
| 计算分子量 | 52kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-PPAR alpha Antibody is directed against mouse PPAR alpha protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest reactivity with this protein from mouse,rat,bovine,dog,golden hamster and boar sources based on 100% homology for the immunogen sequence.Cross-reactivity with PPAR alpha protein from human,chimpanzee and rhesus monkey may also occur as this sequence shows 88% homology (16/18 identities) with the protein from these sources.Cross-reactivity with PPAR alpha homologues from other sources has not been determined.No reactivity is expected against other subtypes of PPAR. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Since their discovery in the early 1990's,the peroxisome proliferator activated receptors (PPARs) have attracted significant attention.This is primarily because PPARs serve as receptors for two very important classes of drugs:the hypolipidemic fibrates and the insulin sensitizing thiazolidinediones.Peroxisome proliferators are non-genotoxic carcinogens that are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed PPARs.Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand.Upon binding fatty acids or hypolipidemic drugs,PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate the expression of target genes.There are 3 known subtypes of PPARs:PPAR-alpha,PPAR-delta and PPAR-gamma.Mostly target genes are involved in the catabolism of fatty acids.Conversely,PPAR-gamma is activated by peroxisome proliferators such as prostaglandins,leukotrienes and Anti diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids.PPAR-gamma may also be involved in adipocyte differentiation.It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 through interaction with specific response elements.Anti-Ppar Antibody is useful for research interested in transcription and metabolic pathways. |
| Uniprot ID | P23204 |
| 基因名全称 | Peroxisome proliferator-activated receptor alpha |
| 推荐稀释比 | ELISA:1:75,000 - 1:125,000 Flow Cytometry:User Optimized IHC:1:100～1:300 IF Microscopy:1～5μg/mL WB:1:500 - 1:2,000 |
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