产品货号：
Z23904
中文名称：
Paxillin/PXN抗体
英文名称：
Anti-Paxillin/PXN Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Paxillin/PXN Antibody |
| 指标别名 | paxillin;PXN |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | PXN |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Paxillin/PXN recombinant protein (Position:A9-K570). |
| 实际分子量 | 65KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PXN(Paxillin) is a signal transduction adaptor protein discovered in 1990 in the laboratory of Keith Burridge.Salgia et al.(1995) mapped the paxillin gene to 12q24 using fluorescence in situ hybridization.The C-terminal region of paxillin contains four LIM domains that target paxillin to focal adhesions,it is presumed through a direct association with the cytoplasmic tail of beta-integrin.The N-terminal region of paxillin is rich in protein–protein interaction sites.The proteins that bind to paxillin are diverse and include protein tyrosine kinases,such as Src and FAK,structural proteins,such as vinculin and actopaxin,and regulators of actin organization,such as COOL/PIX and PKL/GIT.Paxillin is tyrosine-phosphorylated by FAK and Src upon integrin engagement or growth factor stimulation,creating binding sites for the adapter protein Crk.The paxillin protein contains 4 LIM domains,a proline-rich domain containing a consensus SH3-binding site,and 3 potential SH2-binding sites.On Northern blots,paxillin was expressed as a 3.7-kb mRNA in all tissues tested. |
| Uniprot ID | P49023 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | paxillin |
| 蛋白名全称 | Paxillin |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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