产品货号：
Z23889
中文名称：
PMAIP1抗体
英文名称：
Anti-PMAIP1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PMAIP1 Antibody |
| 指标别名 | Noxa;Phorbol-12-myristate-13-acetate-induced protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | PMAIP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa.The immunogen is located within the first 50 amino acids of Noxa. |
| 计算分子量 | 12kDa |
| 成分 | Noxa Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Noxa Antibody is immunoaffinity chromatography purified IgG. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Apoptosis is related to many diseases and development.The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2,p53AIP1,and PUMA.A new p53 target gene,Noxa,was recently identified,which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins.Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins.X-ray irradiation increased p53-dependent Noxa mRNA and protein levels.Noxa,when ectopically expressed,interacted with anti-apoptotic Bcl-2 family members,resulting in the activation of caspase-9.Noxa,like PUMA,localized to mitochondria and induces apoptosis in response to p53.Noxa and PUMA may represent direct mediators of p53-induced apoptosis.Increased levels of p53 and its target gene Noxa was found in the impaired tumor development. |
| Uniprot ID | Q9JM54 |
| 基因名全称 | Phorbol-12-myristate-13-acetate-induced protein 1 |
| 蛋白名全称 | Phorbol-12-myristate-13-acetate-induced protein 1 |
| 推荐稀释比 | Noxa antibody can be used for detection of Noxa by Western blot at at 0.5 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 1μg/mL.For immunofluorescence start at 10μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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