产品货号:
Z23606
中文名称:
PHLPP/PHLPP1抗体
英文名称:
Anti-PHLPP/PHLPP1 Antibody
产品规格:
0.1mg
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-PHLPP/PHLPP1 Antibody |
指标别名 | hSCOP;KIAA0606;PHLPP;PHLPP1;PLEKHE1;SCOP |
克隆性 | Polyclonal |
检验物种 | human |
应用范围 | ELISA,WB,ICC,IF |
基因名称 | PHLPP1 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | PHLPP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PHLPP1.The immunogen is located within amino acids 250 - 300 of PHLPP1. |
计算分子量 | 185kDa |
成分 | PHLPP1 Antibody is supplied in PBS containing 0.02% sodium azide. |
纯化方式 | PHLPP1 Antibody is affinity chromatography purified via peptide column. |
浓度 | 1mg/mL |
产品形态 | 溶液 |
保存条件 | 4℃可保存3个月,-20℃可保存1年。 |
背景资料 | PHLPP1 is a member of the serine/threonine phosphatase family,which are important regulators of Akt serine-threonine kinases (AKT1,AKT2,AKT3) and conventional/novel protein kinase C (PKC) isoforms.PHLPP1 and PHLPP2 have a similar domain structure and have been shown to dephosphorylate and inactivate,distinct Akt isoforms,at one of the two critical phosphorylation sites required for activation:Serine473.PHLPP2 dephosphorylates AKT1 and AKT3,whereas PHLPP1 is specific for AKT2 and AKT3.PHLPP1 promotes apoptosis and may act as a tumor suppressor.Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. |
Uniprot ID | O60346 |
基因名全称 | PH domain and leucine rich repeat protein phosphatase 1 |
蛋白名全称 | PH domain and leucine rich repeat protein phosphatase 1 |
推荐稀释比 | PHLPP1 antibody can be used for detection of PHLPP1 by Western blot at 1 ~ 2μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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