产品货号：
Z23562
中文名称：
OLR1抗体
英文名称：
Anti-OLR1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-OLR1 Antibody |
| 指标别名 | CLEC8A;hLOX 1;Lectin like oxLDL receptor 1;LOX 1;LOX1;OLR1;Ox LDL receptor 1;SCARE1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | OLR1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human LOX-1/OLR1 (162-197aa SFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISY),different from the related rat sequence by thirteen amino acids. |
| 实际分子量 | 31KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | OLR1(oxidized low density lipoprotein (lectin-like) receptor 1) also called CLEC8A,LOX-1,SCARE1,is a receptor protein which belongs to the C-type lectin superfamily.The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL).This gene is mapped on 12p13.2.Incubation of the cells with LDL had no effect on LOX1 expression,but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression;however,very high concentrations of OxLDL caused a decrease in OxLDL expression,perhaps indicating toxic effects on endothelial cells.LOX1 was also expressed in macrophages,but not in vascular smooth muscle cells.The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease.LOX1 expression was detected in all choroidal neovascular membranes,regardless of structure,whereas there was no evidence of LOX1 within the posterior segments of normal eyes.LOX1 plays an active role in the pathogenesis of choroidal neovascularization,especially in ARMD. |
| Uniprot ID | P78380 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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