产品货号：
Z23322
中文名称：
P glycoprotein/ABCB1抗体
英文名称：
Anti-P glycoprotein/ABCB1 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-P glycoprotein/ABCB1 Antibody |
| 指标别名 | ABCB1;CD243;GP170;MDR1;Multidrug resistance protein 1;P glycoprotein;P glycoprotein 1;P-gp |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | ABCB1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 255-280 of human ABCB1 protein. |
| 计算分子量 | 141kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This affinity-purified antibody is directed against human ABCB1 protein.The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.?A BLAST analysis was used to suggest cross-reactivity with ABCB1 protein from human,monkey,dog,mouse,and rat based on 100% homology with the immunizing sequence.Reactivity against homologues from other sources is not known. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | This antibody is suitable for Cancer,Immunology and Nuclear Signaling research.ATP-Binding Cassette Sub-Family B Member 1 (ABCB1,also named P-glycoprotein) is a plasma membrane-associated multidrug transporter that utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells.Unique features of ABCB1 are its very broad substrate specificity and its basal ATPase activity in the absence of transport substrates.Human ABCB1 plays an important role in absorption,distribution,metabolism,excretion and toxicity of pharmacologically relevant drugs.It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anti-cancer drugs.This protein also functions as a transporter across the blood-brain barrier. |
| Uniprot ID | P08183 |
| 基因名全称 | Multidrug resistance protein 1 |
| 推荐稀释比 | ELISA:1:10,000 - 1:50,000 IHC:User Optimized WB:1:200 - 1:2,000 |
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