产品货号：
Z23318
中文名称：
PCSK1抗体
英文名称：
Anti-PCSK1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PCSK1 Antibody |
| 指标别名 | proprotein convertase subtilisin/kexin type 1;BMIQ12;NEC1;PC1;PC3;SPC3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF |
| 基因名称 | PCSK1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human PC1/3(726-740aa DVFYNTKPYKHRDDR),identical to the related mouse and rat sequences. |
| 实际分子量 | 84KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PCSK1(Proprotein Convertase,Subtilisin/Kexin-Type,1),also known as PC1 or NEC1,is an enzyme that in humans is encoded by the PCSK1 gene.Proprotein convertase-1 is a neuroendocrine convertase that belongs to a family of subtilisin-like serine endoproteases that process large precursor proteins into mature bioactive products.By in situ hybridization,Seidah et al.(1991) mapped the NEC1 gene to human chromosome 5q15-q21 and mouse chromosome 13.Ohagi et al.(1996) noted that PC1 initiates the sequential processing of proinsulin to insulin by cleaving the proinsulin molecule on the C-terminal side of the dibasic peptide,arg31-arg32,joining the B-chain and C-peptide.By observing the phenotypic features in patients with PC1 mutations,Jackson et al.(2003) concluded that human intestinal absorptive function is dependent on PC1 activity. |
| Uniprot ID | P29120 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | proprotein convertase subtilisin/kexin type 1 |
| 蛋白名全称 | Neuroendocrine convertase 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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