产品货号：
Z22928
中文名称：
PAK4/5/6抗体
英文名称：
Anti-PAK4/5/6 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PAK4/5/6 Antibody |
| 指标别名 | KIAA1142;p21 activated kinase 4;PAK 4;PAK4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | PAK4/PAK5/PAK6 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human PAK4 around the non-phosphorylation site of S474. |
| 计算分子量 | 64KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.They are divided into two groups,the first of which include PAK1,2 and 3,and can be activated by Cdc42/Rac binding.Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding.The group 1 PAKs are known to be involved in cellular processes such as gene transcription,apoptosis,and cell morphology and motility.Much less is known about the second group,which includes PAK4,5 and 6.These proteins are not activated by Cdc42/Rac binding.PAK4 was initially identified as a novel effector of Cdc42Hs.Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization,showing that it is involved in cytoskeletal reorganization.Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development.PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways. |
| Uniprot ID | O96013/Q9P286/Q9NQU5 |
| 基因名全称 | Serine/threonine-protein kinase PAK 4 |
| 蛋白名全称 | Serine/threonine-protein kinase PAK 4 |
| 推荐稀释比 | WB 1:500～1:2000 ICC 1:200～1:1000 ELISA 1:40000 |
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