产品货号：
Z22926
中文名称：
PAK4抗体
英文名称：
Anti-PAK4 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PAK4 Antibody |
| 指标别名 | KIAA1142;p21 activated kinase 4;PAK 4;PAK4 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | PAK4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | PAK4 antibody was raised against a 13 amino acid synthetic peptide from near the center of human PAK4.The immunogen is located within amino acids 210 - 260 of PAK4. |
| 计算分子量 | 64kDa |
| 成分 | PAK4 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | PAK4 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac.They are divided into two groups,the first of which include PAK1,2 and 3,and can be activated by Cdc42/Rac binding.Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding.The group 1 PAKs are known to be involved in cellular processes such as gene transcription,apoptosis,and cell morphology and motility.Much less is known about the second group,which includes PAK4,5 and 6.These proteins are not activated by Cdc42/Rac binding.PAK4 was initially identified as a novel effector of Cdc42Hs.Co-expression of PAK4 and Cdc42Hs resulted in induction of filopodia and actin polymerization,showing that it is involved in cytoskeletal reorganization.Other experiments have shown PAK4 to be essential for embryonic viability and proper neuronal development.PAK4 has also been implicated in anchorage-independent growth of tumor cells and is required for activation of several cancer prosurvival pathways. |
| Uniprot ID | O96013 |
| 基因名全称 | P21 protein (Cdc42/Rac)-activated kinase 4 |
| 蛋白名全称 | P21 protein (Cdc42/Rac)-activated kinase 4 |
| 推荐稀释比 | PAK4 antibody can be used for the detection of PAK4 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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