产品货号:
Z22803
中文名称:
P glycoprotein/ABCB1抗体
英文名称:
Anti-P glycoprotein/ABCB1 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-P glycoprotein/ABCB1 Antibody |
指标别名 | ABCB1;CD243;GP170;MDR1;Multidrug resistance protein 1;P glycoprotein;P glycoprotein 1;P-gp |
克隆性 | Polyclonal |
检验物种 | human |
应用范围 | WB,IHC,FCM,ELISA |
基因名称 | ABCB1 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | E.coli-derived human P Glycoprotein/ABCB1 recombinant protein (Position:M1-E690). |
实际分子量 | 130~180KD |
成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | P-GP,also called ABCB1 or PGY1,is a glycoprotein that in humans is encoded by the ABCB1 gene.It is mapped to 7q21.12.P-GP is a well-characterized ABC-transporter (which transports a wide variety of substrates across extra- and intracellular membranes) of the MDR/TAP subfamily.It is an important protein of the cell membrane that pumps many foreign substances out of cells.More formally,it is an ATP-dependent drug efflux pump with broad substrate specificity.P-GP is an ATP-dependent drug efflux pump forxenobiotic compounds with broad substrate specificity.It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs.This protein also functions as a transporter in the blood–brain barrier. |
Uniprot ID | P08183 |
推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
基因名全称 | ATP binding cassette subfamily B member 1 |
蛋白名全称 | ATP-dependent translocase ABCB1 |
推荐稀释比 | Western blot (WB) 1:500~2000 Immunohistochemistry in paraffin section (IHC) 1:50~400 Flow cytometry (FCM) 1~3μg/1×106 cells ELISA 1:100~1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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