产品货号：
Z22682
中文名称：
ORAI1抗体
英文名称：
Anti-ORAI1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ORAI1 Antibody |
| 指标别名 | CRACM1;FLJ14466;ORAI1;ORAI1L1;ORAI1L2;Orail L2;ORAT1;Protein orai 1;TMEM142A;Transmembrane protein 142A |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,FCM,ELISA |
| 基因名称 | ORAI1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Orai1 recombinant protein (Position:A49-A301). |
| 实际分子量 | 35～50KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ORAI1(ORAI calcium release-activated calcium modulator 1),also known as°CRACM1,TMEM142A,Calcium release-activated calcium channel protein 1,Protein orai-1,Transmembrane protein 142A,FLJ14466,is a calcium selective ion channel that in humans is encoded by the ORAI1 gene.Orai1 channels play an important role in the activation of T-lymphocytes.The loss of function mutation of Orai1 causes severe combined immunodeficiency(SCID) in humans.The mammalian orai family has two additional homologs,orai2 and orai3.Orai proteins share no homology with any other ion channel family of any other known proteins.They have 4 transmembrane domains and form tetramers.Prakriya et al.showed that ORAI1 is a PM protein,and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments.Glu106-to-asp (E106D) and glu190-to-gln (E190Q) substitutions in transmembrane helices 1 and 3,respectively,diminished calcium ion influx,increased current carried by monovalent cations,and rendered the channel permeable to cesium ion.Prakriya et al.showed that ORAI1 is a PM protein,and that CRAC channel function is sensitive to mutation of 2 conserved acidic residues in the transmembrane segments. |
| Uniprot ID | Q96D31 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 |
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