产品货号：
Z22156
中文名称：
NLRP3抗体
英文名称：
Anti-NLRP3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NLRP3 Antibody |
| 指标别名 | AGTAVPRL;AII;AII/AVP;AVP;C1orf7;Caterpiller protein 1.1;CIAS1;CLR1.1;Cryopyrin;FCAS;FCU;MWS;NALP3;NLRP3;PYPAF1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB,IHC,FCM,ICC/IF,IF |
| 基因名称 | NLRP3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human CIAS1(12-31aa RYLEDLEDVDLKKFKMHLED),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 118KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NLRP3(NLR FAMILY,PYRIN DOMAIN-CONTAINING 3),also known as CIAS1,CRYOPYRIN,NALP3 or PYPAF1,is a protein that in humans is encoded by the NLRP3(NOD-like receptor family,pryin domain containing 3) gene.The NLRP3 gene encodes a pyrin-like protein expressed predominantly in peripheral blood leukocytes.And the NLRP3 gene is mapped on 1q44.NLRP3 interacts with apoptosis-associated speck-like protein containing a CARD(ASC).The encoded protein may play a role in the regulation of inflammation and apoptosis.Mutation of the NALP3 nucleotide-binding domain reduced ATP binding,CASP1 activation,IL1B production,cell death,macromolecular complex formation,self-association,and association with ASC.Consistent with an essential role for Nlrp3 inflammasomes in antifungal immunity,Gross et al.showed that Nlrp3-deficient mice are hypersusceptible to C.albicans infection.Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells.The NLRP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance. |
| Uniprot ID | Q96P20 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | NLR family,pyrin domain containing 3 |
| 蛋白名全称 | NACHT,LRR and PYD domains-containing protein 3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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