产品货号：
Z21942
中文名称：
Norrin/NDP抗体
英文名称：
Anti-Norrin/NDP Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Norrin/NDP Antibody |
| 指标别名 | ND;EVR2;FEVR;Norrin;Norrie disease protein |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,ICC |
| 基因名称 | NDP |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Norrin antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human Norrin.The immunogen is located within the first 50 amino acids of Norrin. |
| 计算分子量 | 15kDa |
| 成分 | Norrin Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Norrin Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Norrie disease is an X-linked genetic disorder characterized by progressive atrophy of the eyes,mental disturbances and deafness.The gene responsible for this disease was initially identified through positional cloning.Norrin,the gene product,encodes a small secreted,cysteine-rich protein that is thought to act as a ligand for the Wnt-receptor/beta-catenin signal pathway despite having sequence homology with the Wnt family of proteins.Mice lacking this gene have abnormal blood vessel growth in the vitreous and a disorganized retina;transgenic ectopic expression of Norrin restores normal retinal vasculature.Recent evidence shows that Norrin can attenuate tPA and uPA-mediated death of transformed rat retinal ganglion cells (RGC-5) by activating the Wnt/beta-catenin pathway and regulating the phosphorylation of LRP-1,a cell surface receptor for tPA and uPA,suggesting the Norrin may function in vivo by regulating kinases which may alter the phosphorylation of LRP-1. |
| Uniprot ID | Q00604 |
| 基因名全称 | Norrie disease (pseudoglioma) |
| 蛋白名全称 | Norrie disease (pseudoglioma) |
| 推荐稀释比 | Norrin antibody can be used for detection of Norrin by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunocytochemistry starting at 5μg/mL.Antibody validated:Western Blot in human samples and Immunocytochemistry in human samples.All other applications and species not yet tested. |
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