产品货号：
Z21846
中文名称：
NR1I2抗体
英文名称：
Anti-NR1I2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NR1I2 Antibody |
| 指标别名 | PXR;NR1I2;SXR;Pregnane X receptor |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,FCM,ELISA |
| 基因名称 | NR1I2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human PXR/NR1I2 recombinant protein (Position:E7-A395). |
| 实际分子量 | 50KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | In the field of molecular biology,the pregnane X receptor (PXR),also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1,group I,member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1,group I,member 2) gene.It is mapped to 3q13.33.This gene product belongs to the nuclear receptor superfamily,members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4,binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR.It is activated by a range of compounds that induce CYP3A4,including dexamethasone and rifampicin.Several alternatively spliced transcripts encoding different isoforms,some of which use non-AUG (CUG) translation initiation codon,have been described for this gene.Additional transcript variants exist,however,they have not been fully characterized. |
| Uniprot ID | O75469 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (ELISA)： 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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