产品货号：
Z21826
中文名称：
NPC1抗体
英文名称：
Anti-NPC1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NPC1 Antibody |
| 指标别名 | NPC1;NPC intracellular cholesterol transporter 1;Niemann-Pick C1 protein |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,Direct ELISA |
| 基因名称 | NPC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human NPC1 recombinant protein (Position:R116-D620). |
| 实际分子量 | 140KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Niemann-Pick disease,type C1 (NPC1) is a membrane protein that mediates intracellular cholesterol trafficking in mammals.In humans it is encoded by the NPC1 gene (chromosome location 18q11).This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.It is predicted to have a cytoplasmic C-terminus,13 transmembrane domains,and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus.This protein transports low-absorbance lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.Defects in this gene cause Niemann-Pick type C disease,a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments. |
| Uniprot ID | O15118 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | NPC intracellular cholesterol transporter 1 |
| 蛋白名全称 | NPC intracellular cholesterol transporter 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Direct ELISA 1:100～1000 |
相关搜索：NPC1抗体，NPC1多抗，Anti-NPC1 Antibody