产品货号：
Z21822
中文名称：
NPC1抗体
英文名称：
Anti-NPC1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NPC1 Antibody |
| 指标别名 | Niemann Pick C1 protein;Niemann Pick disease;type C1;NPC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | NPC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | NPC1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human NPC1.The immunogen is located within the last 50 amino acids of NPC1. |
| 计算分子量 | 142kDa |
| 成分 | NPC1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | NPC1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids.The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.NPC1,in addition to FTO,MC4R,and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.This anti-NPC1 antibody will not cross-react to NPC2,another gene whose defects also result in Niemann-Pick type C disease. |
| Uniprot ID | O15118 |
| 基因名全称 | Niemann-Pick disease,type C1 |
| 蛋白名全称 | Niemann-Pick disease,type C1 |
| 推荐稀释比 | NPC1 antibody can be used for detection of NPC1 by Western blot at 1μg/mL.Antibody can also be used for immunohistochemistry starting at 2.5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples.All other applications and species not yet tested. |
相关搜索：NPC1抗体，NPC1多抗，Anti-NPC1 Antibody